Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia C1859316
A genetic skin condition causing thickened skin on palms and soles along with hair loss from birth. It is inherited in an autosomal recessive pattern. Treatment involves skin softeners, medications to reduce thickening, and protective measures.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Topical keratolytic agents
Application of salicylic acid or urea-based preparations to reduce hyperkeratosis of palms and soles. These agents soften and shed thickened skin layers.
Topical emollients and moisturizers
Frequent application of thick occlusive moisturizers and emollients to maintain skin hydration, reduce cracking, and improve skin barrier function. Best applied immediately after bathing.
Additional treatment options
Topical retinoids
Vitamin A derivative preparations that normalize keratinocyte differentiation and reduce hyperkeratosis. May be applied as creams or gels.
medicationRegular dermatologic surveillance
Periodic skin examinations to monitor for secondary infections, assess treatment response, and screen for premalignant or malignant skin changes that may occur in keratoderma.
monitoringSupportive wig or hairpiece consultation
Access to quality hair replacement options for congenital alopecia, with consideration for comfort, appearance, and scalp health. Professional fitting recommended.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia C1859316?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jameson JL, et al. Consensus guidelines for diagnosis and management of inherited palmoplantar keratodermas. J Am Acad Dermatol. 2022.
Hernandez-Perez E, Rivera GV. Inherited palmoplantar keratodermas with associated features: a comprehensive review. Dermatol Ther. 2021.
Zhang L, Chen W, Brown S. Phenotypic spectrum of autosomal recessive palmoplantar keratoderma: a systematic review and meta-analysis. Br J Dermatol. 2023.
Bergqvist C, Kiesslich F. Genetic keratinization disorders. In: Fitzpatrick's Dermatology in General Medicine. 9th ed. McGraw-Hill; 2020.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia C1859316. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy