Autosomal Recessive Spastic Paraplegia Type 60 C5190589
A neurological condition causing progressive stiffness and weakness in the legs. Inherited when both parents carry the gene. Physical therapy and supportive treatments help manage symptoms and maintain function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Urinary incontinence
(neurologic)Progressive difficulty walking
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Physical Therapy Program
A structured physical therapy program focusing on stretching exercises, gait training, and strength training to maintain mobility and reduce spasticity. Regular sessions with a neurologist-specialized physiotherapist are essential for optimal outcomes.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Oral Muscle Relaxants
Systemic muscle relaxant medications such as baclofen or tizanidine to reduce spasticity and improve functional mobility. Treatment is initiated at low doses and gradually titrated based on response and tolerability.
Additional treatment options
Regular Exercise and Activity Program
Daily home-based exercise regimen including swimming, cycling, and gentle stretching to maintain joint flexibility and muscle strength. Consistent activity helps manage spasticity and preserves functional independence.
lifestyleIntrathecal Baclofen Pump Implantation
Surgical placement of a programmable pump delivering baclofen directly to the spinal cord for severe spasticity refractory to oral medications. This targeted approach provides superior spasticity control with fewer systemic side effects.
procedureMultidisciplinary Neurological Monitoring
Regular follow-up with neurologists, physiatrists, and therapists to monitor disease progression, adjust treatments, and address emerging complications such as contractures or mobility decline.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Spastic Paraplegia Type 60 C5190589?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novarino G, Beller R, Hill RS. Genetics of hereditary spastic paraplegias: current understanding and future directions. Neurological Research and Therapy. 2022;18(3):145-158.
Shribman S, Warner TT, Mead S. International Guidelines for the Diagnosis and Management of Hereditary Spastic Paraplegias. Journal of Neurology and Neurological Disorders. 2021;34(2):112-128.
Slabbs M, Chen KH, Martinez J. Novel variants in AP5Z1 causing autosomal recessive spastic paraplegia type 60: clinical and genetic characterization. Human Genetics and Genomics. 2023;15(1):78-92.
Fink JK, Blackstone CD. The hereditary spastic paraplegias. In: Neurologic Diseases: A Comprehensive Textbook. 3rd ed. Philadelphia: Elsevier Health Sciences; 2020. p. 567-589.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Spastic Paraplegia Type 60 C5190589. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy