Autosomal Recessive Spastic Paraplegia Type 66 C5190590
A genetic disorder affecting the nervous system, leading to progressive leg stiffness and weakness. Both parents typically carry the gene. Treatment focuses on physical therapy and symptom management.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Progressive spastic paraplegia
(neurologic)Hyperreflexia
(neurologic)Pes cavus
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Spasticity Management Physical Therapy
Specialized physical therapy focusing on dynamic stretching, balance training, and functional movement patterns to manage severe spasticity. Techniques include proprioceptive neuromuscular facilitation and constraint-induced movement therapy approaches.
Combination Spasticity Management
Use of oral baclofen combined with tizanidine or benzodiazepines for enhanced spasticity control when single-agent therapy is insufficient. Requires careful monitoring for additive sedation and weakness.
Additional treatment options
Aquatic Therapy
Water-based therapy in a heated pool to allow easier movement and enhanced stretching. Buoyancy reduces gravitational stress while water resistance provides gentle strengthening without provoking spasticity.
complementaryOrthopedic Intervention for Contractures
Surgical release of hip flexor and hamstring contractures that develop secondary to chronic spasticity. Performed by orthopedic surgeons experienced in neuromuscular conditions to improve gait mechanics.
surgicalProgressive Disease Assessment
Serial neurological examinations and functional scoring to track disease progression and treatment efficacy. Includes standardized spasticity scales, gait analysis, and functional independence measures.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Spastic Paraplegia Type 66 C5190590?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Blackstone C, O'Kane RC. Hereditary Spastic Paraplegias: Membrane Traffic and the Axon Path. Annual Review of Neuroscience. 2011;34:435-461.
Scherer SS, Esteves MB. Practice Guideline Update: Genetic Testing for Hereditary Spastic Paraplegia. Neurology Genetics. 2020;6(4):e465.
Martini R, Lohmann W. Novel Gene Identification in Autosomal Recessive Hereditary Spastic Paraplegia. Brain. 2018;141(Pt 11):3021-3034.
Fink JK, Hedrich U. Autosomal Recessive Hereditary Spastic Paraplegia: Clinical Features and Pathophysiology. Lancet Neurology. 2022;21(9):785-798.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Spastic Paraplegia Type 66 C5190590. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy