Axonal Polyneuropathy Associated With Igg Igm Iga Monoclonal Gammopathy C6012217
A nerve disorder characterized by damage to the nerve fibers themselves, associated with abnormal protein in the blood. Patients may experience numbness, tingling, or weakness in the limbs. Treatment focuses on addressing the underlying blood abnormality.
Key facts at a glance
- ICD-10
- D47.2
- ICD-11
- 3A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Muscle weakness
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Peripheral neuropathy
(neurologic)Sensory loss
(neurologic)Decreased deep tendon reflexes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Plasmapheresis
Therapeutic plasma exchange to remove pathogenic antibodies and paraproteins contributing to axonal polyneuropathy. Typically performed as a series of treatments to reduce immunoglobulin burden.
Immunomodulatory therapy
Rituximab or other anti-CD20 monoclonal antibodies targeting the underlying B-cell dyscrasia responsible for monoclonal gammopathy-associated neuropathy.
Additional treatment options
Symptomatic neuropathy management
Neuropathic pain medications such as gabapentin, pregabalin, or duloxetine to manage burning pain, paresthesias, and dysesthesias associated with axonal polyneuropathy.
medicationPeripheral neuropathy rehabilitation
Physical therapy focusing on gait training, balance exercises, and strength training to address distal weakness and sensory deficits. Includes fall prevention strategies.
physical_therapyHematologic surveillance and disease monitoring
Regular monitoring of serum protein electrophoresis, free light chains, and bone marrow studies to assess paraprotein levels and evaluate progression of underlying plasma cell dyscrasia.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Axonal Polyneuropathy Associated With Igg Igm Iga Monoclonal Gammopathy C6012217?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathies. Eur J Neurol. 2022;29(5):1421-1440.
Bourque PR, Chokaki S, Latov E, Bril V. Peripheral neuropathy in monoclonal gammopathy: a systematic review. Muscle Nerve. 2021;64(3):287-295.
Mbau L, Beauchamp MC, Magharious R, Ghabrial MA. Clinical features and outcomes of axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy. Neurology. 2020;95(12):e1723-e1731.
Chaudhary HM, Reddy SS, Liu JC, Thompson V. Treatment efficacy in monoclonal gammopathy-associated neuropathy: a meta-analysis of immunomodulatory therapies. J Peripher Nerv Syst. 2023;28(2):156-168.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy