B Cell Childhood Acute Lymphoblastic Leukemia C0279584
The most common childhood cancer. Modern treatment leads to excellent survival rates. Treated with multi-drug chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Fatigue
(hematologic)Pallor
(hematologic)Fever
(immune)Severe bone pain
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Multi-Agent Chemotherapy Protocol
Intensive combination chemotherapy regimen typically spanning 2-3 years, combining multiple anticancer drugs to eliminate leukemic cells from the blood and bone marrow. Treatment phases include induction, consolidation, interim maintenance, delayed intensification, and maintenance therapy.
Additional treatment options
Hematopoietic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of healthy stem cells to restore bone marrow function, typically considered when leukemia recurs or fails to respond to initial chemotherapy. The procedure requires a compatible donor and extensive pre-transplant evaluation.
procedureTargeted Biologic Therapy
Monoclonal antibodies or targeted agents that specifically attack leukemic cells while sparing normal cells. These newer therapies may be used in combination with chemotherapy or for relapsed disease.
medicationCentral Nervous System Prophylaxis
Preventive treatment to stop leukemic spread to the brain and spinal cord, including intrathecal chemotherapy injections directly into the cerebrospinal fluid. May be combined with cranial radiation in high-risk cases.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is B Cell Childhood Acute Lymphoblastic Leukemia C0279584?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hunger SP, Mullighan CG. Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2015;373(16):1541-1552.
Pui CH, Yang JJ, Hunger SP, et al. Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. J Clin Oncol. 2015;33(27):2938-2948.
Taur PDB, Arora M, Seth T. Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis. Biol Blood Marrow Transplant. 2020;26(5):937-947.
Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018;378(5):439-448.
Medication Comparisons
Compare medications used to treat B Cell Childhood Acute Lymphoblastic Leukemia C0279584. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy