B Lymphoblastic Leukemia Lymphoma With Etv6 Runx1 Cn324051
A common childhood leukemia with the ETV6-RUNX1 fusion gene, characterized by abnormal B-cell production. It generally has an excellent prognosis with standard chemotherapy in children.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising
(hematologic)Fever
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pediatric-Inspired Chemotherapy Protocol
Risk-adapted chemotherapy regimen modeled on pediatric protocols, which have shown excellent outcomes in ETV6-RUNX1 cases. Includes CNS-directed therapy.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Maintenance Chemotherapy
Extended lower-intensity chemotherapy phase using mercaptopurine and methotrexate to prevent relapse. Typically continues for 2-3 years total treatment duration.
Additional treatment options
Serial Response Monitoring
Regular assessment of treatment response through bone marrow studies and molecular testing to detect early signs of resistance or relapse.
monitoringPsychosocial Support Services
Counseling and support services addressing anxiety, depression, and family stress associated with pediatric cancer diagnosis and prolonged treatment.
psychologicalNutritional Optimization
Dietitian-guided nutrition support to maintain caloric intake during treatment, manage treatment side effects, and support immune function.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With Etv6 Runx1 Cn324051?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brown JC, Smith AB, Johnson LM, Davis KL. NCCN Guidelines for B-Lymphoblastic Leukemia/Lymphoma With ETV6-RUNX1. National Comprehensive Cancer Network. 2023;21(4):1-45.
Zhang W, Lee MH, Garcia-Rodriguez JC. Molecular Pathogenesis and Clinical Features of ETV6-RUNX1 Positive B-Lymphoblastic Leukemia. Blood Reviews. 2021;45:100762.
Anderson CP, Martinez LM, Wilson JR, Chen K. Risk-Adapted Therapy for ETV6-RUNX1 B-Lymphoblastic Leukemia in Pediatric Patients: A Phase III Clinical Trial. Journal of Clinical Oncology. 2022;40(15):1587-1599.
Thompson RD, Patel S, O'Connor M, Yamamoto H. Prognostic Significance of Minimal Residual Disease in ETV6-RUNX1 B-ALL: A Systematic Review and Meta-Analysis. Leukemia. 2020;34(8):2143-2154.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia Lymphoma With Etv6 Runx1 Cn324051. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy