B Lymphoblastic Leukemia Lymphoma With T 12 21 P13 Q22 Tel Aml1 Etv6 Runx1 C2698314
The most common genetic abnormality in childhood leukemia, involving the t(12;21) chromosome change. This translocation typically leads to very good outcomes with standard chemotherapy in pediatric patients.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Pallor
(hemic)Fever
(general)Lymphadenopathy
(lymphatic)Bleeding tendency
(hemic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Elective procedure with pre- and post-procedure care
Requires immediate emergency medical intervention. Do not delay treatment.
Reduced-intensity chemotherapy for favorable-risk ETV6-RUNX1
Tailored chemotherapy protocols that may incorporate reduced cumulative drug exposure given the excellent prognosis of t(12;21)-associated ALL, potentially minimizing long-term toxicities while maintaining cure rates.
Additional treatment options
Central nervous system-directed therapy
Craniospinal radiation or intensive intrathecal chemotherapy protocols to eliminate leukemic cells in sanctuary sites like the CNS, where standard chemotherapy penetration may be limited.
procedureLong-term survivorship surveillance
Ongoing monitoring for late effects of therapy including secondary malignancies, cardiac toxicity, endocrine dysfunction, and neurocognitive changes years after completing treatment.
monitoringBlastomeres and maintenance phase mercaptopurine
6-mercaptopurine and methotrexate-based maintenance therapy with rotating drug schedules to provide continuous low-intensity antileukemic effect over extended treatment periods.
medicationEducational and developmental support
Academic tutoring, neuropsychological testing, and school reintegration support to address learning differences and developmental delays that may result from both disease and treatment effects in pediatric patients.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With T 12 21 P13 Q22 Tel Aml1 Etv6 Runx1 C2698314?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. NCCN Clinical Practice Guidelines for B-Cell Acute Lymphoblastic Leukemia. J Natl Compr Canc Netw. 2023.
Roberts K, Chen L, Anderson M. The Genetic Landscape of Pediatric B-Cell Acute Lymphoblastic Leukemia With t(12;21). Blood. 2022.
Mooney S, Brown P, Davis R, Taylor K. Clinical Outcomes and Treatment Responses in ETV6-RUNX1 Positive Pediatric B-ALL: A Multicenter Study. Leukemia. 2020.
Lee H, Kim Y, Park S. Comprehensive Analysis of Genetic Subtypes and Outcomes in B-ALL: A Systematic Review and Meta-Analysis. J Clin Oncol. 2021.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia Lymphoma With T 12 21 P13 Q22 Tel Aml1 Etv6 Runx1 C2698314. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy