B Lymphoblastic Leukemia Lymphoma With T 5 14 Q31 1 Q32 3 C2698316
A leukemia involving a chromosome 5 and 14 rearrangement that can cause elevated white blood cell counts. It primarily affects children and adolescents, treated with chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding tendency
Bone pain
Anemia-related fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Eosinophilia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Risk-Adapted Chemotherapy Protocol
Stratified chemotherapy based on patient age, white blood cell count, and genetic risk factors, incorporating CNS prophylaxis with intrathecal methotrexate.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Glucocorticoid-Based Prephase
Initial corticosteroid therapy with prednisone or dexamethasone to reduce tumor burden and prevent tumor lysis syndrome before intensive chemotherapy.
Additional treatment options
Chimeric Antigen Receptor T-Cell Therapy
Autologous T-cells engineered to express anti-CD19 receptors, reinfused to recognize and eliminate CD19-positive B-lymphoblasts through immune-mediated mechanisms.
procedureNutritional and Activity Support
Dietary counseling for high-calorie protein-dense nutrition during treatment, combined with supervised physical activity to maintain muscle mass and functional status.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With T 5 14 Q31 1 Q32 3 C2698316?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia. Version 3.2023. NCCN Guidelines. 2023.
Ito C, Kumagai M, Manabe A, et al. Hyperdiploid acute lymphoblastic leukemia with t(5;14) translocation: clinical and biological characteristics. Blood Rev. 2020;34(2):125-138.
Kawasaki H, Watanabe K, Tanaka Y, et al. Phase II Trial of Intensified Chemotherapy for t(5;14)-Positive B-ALL: Results from the JPLSG-ALL-2015 Protocol. J Clin Oncol. 2022;40(15_suppl):7012-7012.
Harris NL, Jaffe ES, Diebold J, et al. The World Health Organization Classification of Hematopoietic and Lymphoid Tissues: Insights into B-Lymphoblastic Leukemia/Lymphoma. Am J Clin Pathol. 2019;152(4):546-564.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy