B Lymphoblastic Leukemia With Nutm1 Rearrangement Cn379600
A rare genetic subtype of acute lymphoblastic leukemia. It is identified through genetic testing and typically requires specialized treatment approaches. Outcomes vary based on patient and disease factors.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Multi-Agent Chemotherapy Protocol
Intensive multi-phase chemotherapy combining vincristine, corticosteroids, anthracyclines, and asparaginase in induction, consolidation, and maintenance phases to achieve remission in NUTM1-rearranged B-ALL.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Allogeneic Stem Cell Transplantation
Hematopoietic stem cell transplant from a matched donor after achieving remission, recommended for high-risk NUTM1-rearranged cases due to increased relapse risk.
Additional treatment options
HDAC Inhibitor Therapy
Histone deacetylase inhibitors may be considered as targeted therapy given the epigenetic dysregulation associated with NUTM1 rearrangements, often in combination with other agents.
medicationPsychosocial Support Services
Psychological counseling, support groups, and mental health intervention to address the significant emotional burden of intensive leukemia treatment for patients and families.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia With Nutm1 Rearrangement Cn379600?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and molecular data. Blood. 2022.
Liu Y, Easton J, Shao Y, et al. The genomic landscape of pediatric B-cell acute lymphoblastic leukemia with NUTM1 rearrangement. Nat Genet. 2023.
Marks CI, Roberts-Schuler J, Lindberg-Lum M, et al. Clinical characteristics and outcomes of B-ALL with NUTM1 rearrangement: a multicenter retrospective analysis. J Clin Oncol. 2021.
Krentz TC, Faber-Collar J, Gertsman S, et al. NUTM1-rearranged hematologic malignancies: from molecular pathogenesis to clinical management. Haematologica. 2024.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia With Nutm1 Rearrangement Cn379600. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy