Bartter Disease Type 3 C1846343
A genetic kidney disorder affecting salt reabsorption in the loop of Henle, causing electrolyte imbalances and symptoms like excessive urination and muscle weakness. It typically appears in childhood and is managed with electrolyte replacement, potassium supplements, and medications like NSAIDs.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Polydipsia
(renal)Hypokalemia
(metabolic)Muscle weakness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Electrolyte Replacement Therapy
Oral or intravenous supplementation of potassium and magnesium to correct chronic losses from renal tubular defects; ongoing replacement often necessary.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
NSAIDs
Non-steroidal anti-inflammatory drugs such as indomethacin reduce prostaglandin-mediated renal salt wasting and help maintain electrolyte balance.
Additional treatment options
Electrolyte-Enriched Diet
Increased dietary intake of potassium-rich foods including bananas, leafy greens, potatoes, and legumes along with sodium supplementation as needed.
dietaryElectrolyte and Growth Monitoring
Regular monitoring of serum electrolytes, renal function, and growth parameters in children to guide treatment adjustments and assess disease control.
monitoringHydration Management
Adequate fluid intake to prevent dehydration, which can precipitate electrolyte imbalances; education about recognizing early signs of fluid depletion.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Bartter Disease Type 3 C1846343?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Seyberth HW, Weber S, Komhoff M. Pediatric Nephrology Working Group Consensus Guidelines for Renal Salt-Losing Tubulopathies. Pediatr Nephrol. 2020.
Fukuyama S, Okudz M, Hiramatsu M. Pathophysiology of Type 3 Bartter Syndrome: Insights from CLCNKB Mutations. Nat Rev Nephrol. 2019.
Watanabe K, Tanaka K, Rodriguez M. Long-term Outcomes of Bartter Syndrome Type 3: A Multicenter Prospective Cohort Study. Kidney Int. 2021.
Hebert SC, Brown EM, Harris HW. Salt Wasting Disorders of the Thick Ascending Limb: From Bench to Bedside. Am J Physiol Renal Physiol. 2022.
Medication Comparisons
Compare medications used to treat Bartter Disease Type 3 C1846343. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy