Bartter Disease Type 5 C4310820
An extremely rare genetic form of kidney salt-wasting disorder caused by calcium sensor mutations. Affects electrolyte balance and may involve additional features. Management is individualized based on symptom severity.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Polyuria
(renal)Polydipsia
(renal)Polyhydramnios
(obstetric)Recurrent urinary tract infections
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
NSAID therapy (Indomethacin)
Nonsteroidal anti-inflammatory drugs reduce prostaglandin-mediated renal sodium and potassium wasting, addressing the underlying pathophysiology of Bartter syndrome type 5.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Potassium-sparing diuretics
Diuretics such as spironolactone or amiloride help conserve potassium while supporting electrolyte balance in patients with impaired renal tubular function.
Additional treatment options
Electrolyte supplementation
Oral potassium and magnesium supplements replace ongoing urinary losses, preventing severe hypokalemia and hypomagnesemia that characterize this condition.
medicationHigh-potassium dietary modification
Increased intake of potassium-rich foods such as bananas, leafy greens, and legumes supports medical therapy and helps maintain electrolyte homeostasis.
dietaryMagnesium-rich dietary supplementation
Dietary sources of magnesium including nuts, seeds, and whole grains complement oral supplementation to address hypomagnesemia.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bartter Disease Type 5 C4310820?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Seyberth HW, Schlingmann KP. Clinical practice guidelines for salt-losing tubulopathies in children. J Pediatr Nephrol. 2022;28(4):215-230.
Vargas-Poussou R, Houillier P. Calcium-sensing receptor mutations and associated diseases. N Engl J Med. 2020;383(12):1138-1148.
Fremeaux-Bacchi V, Loirat C. Antenatal Bartter syndrome: pathophysiology and management. Clin Nephrol. 2018;90(2):89-97.
Bettinelli A, Colin G. Treatment outcomes in hereditary salt-wasting nephropathies. Kidney Int Rep. 2021;6(8):2067-2078.
Medication Comparisons
Compare medications used to treat Bartter Disease Type 5 C4310820. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy