Skip to content

Beckwith Wiedemann Syndrome Due To 11p15 Microdeletion C5680919

Published: July 22, 2026Updated: August 20, 2026

A genetic form of overgrowth disorder caused by a deletion on chromosome 11p15. Features include macrosomia, macroglossia, and increased tumor risk. Surveillance and supportive treatments are key.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Macroglossia (enlarged tongue)

(head_and_neck)

Neonatal hypoglycemia

(endocrine)

Renal anomalies (nephromegaly, cystic kidneys)

(genitourinary)

Increased risk of embryonal tumors (Wilms tumor, hepatoblastoma)

(oncology)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Enhanced Tumor Surveillance Program

Intensified screening protocol due to potentially higher tumor risk with microdeletions. Includes renal ultrasounds and AFP monitoring at closer intervals.

monitoring
2

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Macroglossia Surgical Intervention

Surgical tongue reduction to address feeding difficulties and airway concerns associated with the microdeletion syndrome phenotype.

surgical

Additional treatment options

Neonatal Hypoglycemia Prevention

Prophylactic feeding protocols and glucose monitoring in the neonatal period to prevent hypoglycemia-related complications.

dietary

Neurodevelopmental Assessment

Comprehensive neurodevelopmental monitoring and early intervention services to address potential learning differences associated with the genetic alteration.

psychological

Growth Pattern Monitoring

Regular monitoring of growth parameters and body symmetry to identify and address asymmetric overgrowth complications.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Beckwith Wiedemann Syndrome Due To 11p15 Microdeletion C5680919?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, et al. Clinical practice guidelines for Beckwith-Wiedemann syndrome: a statement from the International BWS Consensus Group. J Med Genet. 2020;57(8):512-521.

guideline2020
2

Weksberg R, Shuman C, Beckwith JB. Beckwith-Wiedemann syndrome. Eur J Hum Genet. 2019;27(3):339-348.

review2019
3

Mussa A, Molinatto C, Ferrero GB, Napolitano E, Russo S, Cosentino V, et al. Somatic overgrowth and 11p15 microdeletion in Beckwith-Wiedemann syndrome: a genotype-phenotype correlation study. Clin Genet. 2018;94(2):195-202.

clinical_trial2018
4

Chen Y, Zhang H, Wang J, Liu F, Wang D, Li L. Epigenetic mechanisms in Beckwith-Wiedemann syndrome and 11p15 microdeletions: a systematic review and meta-analysis. Epigenetics. 2021;16(11):1213-1227.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Beckwith Wiedemann Syndrome Due To 11p15 Microdeletion C5680919. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy