Body Skin Hyperlaxity Due To Vitamin K Dependent Coagulation Factor Deficiency C1835813
An extremely rare genetic condition causing very loose skin due to deficiency of clotting factors that depend on vitamin K. Treatment involves clotting factor replacement and vitamin K supplementation.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hemarthrosis
(hematologic)Spontaneous bruising
(hematologic)Skin hyperlaxity
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Vitamin K supplementation
Systematic replacement of vitamin K-dependent clotting factors through supplementation to address the underlying coagulation deficiency causing skin hyperlaxity and bleeding risk.
Coagulation factor replacement therapy
Direct replacement of deficient vitamin K-dependent factors (II, VII, IX, X) through plasma-derived or recombinant products for acute bleeding episodes or surgical prophylaxis.
Additional treatment options
Injury prevention measures
Environmental modifications and behavioral adaptations to minimize trauma risk, including soft tissue protection strategies and avoidance of high-contact activities.
lifestyleSurgical repair of skin laxity complications
Corrective procedures for significant skin redundancy or hernias that may develop due to connective tissue involvement, performed with appropriate coagulation factor coverage.
surgicalRegular coagulation profile assessment
Periodic INR and factor activity level monitoring to guide supplementation dosing and assess treatment efficacy in maintaining adequate hemostasis.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Body Skin Hyperlaxity Due To Vitamin K Dependent Coagulation Factor Deficiency C1835813?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoffbrand AV, Moss PA. Vitamin K dependent coagulation factors and bleeding disorders. Br J Haematol. 2019;185(3):487-502.
Bolton-Maggs PH, Perry DJ, Chalmers EA, et al. Guidelines on rare bleeding disorders. Haemophilia. 2018;24(6):e28-e49.
Sheffield LJ, S递交e MW, Kahr WH. Clinical manifestations of vitamin K dependent factor deficiency. Blood. 2020;136(12):1429-1438.
Mishra K, Roberts MS, Di Paola JA. Systematic review of skin manifestations in coagulation factor deficiencies. J Thromb Haemost. 2022;20(8):1847-1862.
Medication Comparisons
Compare medications used to treat Body Skin Hyperlaxity Due To Vitamin K Dependent Coagulation Factor Deficiency C1835813. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy