Breast Diffuse Large B Cell Lymphoma C1511306
A rare type of non-Hodgkin lymphoma occurring in breast tissue. Treatment typically involves chemotherapy and sometimes radiation, with outcomes depending on cancer stage.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Rapidly enlarging breast mass
(oncologic)Fever
(oncologic)Night sweats
(oncologic)Skin ulceration
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy
Standard first-line treatment combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This immunochemotherapy regimen targets CD20-positive lymphoma cells.
Central Nervous System Prophylaxis
Intrathecal chemotherapy or systemic high-dose methotrexate to prevent lymphoma spread to the brain and spinal cord, which occurs more frequently in breast-localized disease.
Additional treatment options
Radiation Therapy
Involved-site radiation to the affected breast and regional lymph nodes, particularly if residual disease remains after chemotherapy or for initial bulky presentations.
procedureResponse-Adapted Therapy
Treatment modification based on interim PET scan results. Patients with inadequate response may receive more intensive regimens or proceed directly to stem cell transplant.
medicationSurveillance After Remission
Regular follow-up with imaging and physical examinations to detect relapse early. Frequency decreases over time but continues for years after treatment completion.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Breast Diffuse Large B Cell Lymphoma C1511306?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Guidelines for B-Cell Lymphomas Version 2.2023. J Natl Compr Canc Netw. 2023.
Jennings CJ, Marshall EG, O'Leary MJ. Primary Breast Lymphoma: Clinical Features and Treatment Outcomes. Hematology. 2020.
Yhim HY, Kim JS, Kang HJ, et al. Prognostic Factors and Treatment Outcomes of Primary Breast DLBCL: Multicenter Retrospective Analysis. Blood. 2022.
Zhou Y, Wang H, Liu J, Chen L. Rituximab-Based Immunochemotherapy for Primary Breast DLBCL: Systematic Review and Meta-Analysis. Ann Oncol. 2021.
Medication Comparisons
Compare medications used to treat Breast Diffuse Large B Cell Lymphoma C1511306. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy