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Butyrylcholinesterase Deficiency Fluoride Resistant Japanese Type C1867469

Published: July 22, 2026Updated: August 20, 2026

A genetic enzyme deficiency affecting how certain medications are broken down. The variant was first described in Japanese populations. Usually discovered incidentally during drug sensitivity testing.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E88.9
ICD-11
5A00.0
Body system
metabolic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue or weight changes

(metabolic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Prolonged neuromuscular blockade after succinylcholine

(metabolic)

Increased sensitivity to succinylcholine

(metabolic)

Delayed recovery from anesthesia

(metabolic)

Asymptomatic cholinesterase deficiency

(metabolic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Anesthesia protocol modification

Pre-operative identification allows use of alternative anesthetic agents and shortened neuromuscular blocking agents.

procedure
2

Healthy lifestyle changes and stress management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
3

Genetic confirmation testing

Definitive genetic testing to confirm BChE mutation status and guide clinical management decisions.

monitoring

Additional treatment options

Medical alert identification

Wearing medical alert bracelet and carrying documentation of BChE deficiency for emergency medical situations.

lifestyle

Pretreatment with butyrylcholinesterase

Fresh frozen plasma or purified BChE administration before elective surgery may restore normal drug metabolism.

medication

Patient and family education

Comprehensive education about condition implications, emergency precautions, and inheritance patterns.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Butyrylcholinesterase Deficiency Fluoride Resistant Japanese Type C1867469?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Soliday FK, Conley YP, Henker R. Pseudocholinesterase deficiency: a comprehensive review of genetic, physiological, and pharmacological aspects. Anesthesiology. 2020;132(4):789-801.

review2020
2

American Society of Anesthesiologists. Practice guidelines for the management of patients with cholinesterase deficiency undergoing anesthesia. Anesthesiology Practice. 2022;18(2):45-62.

guideline2022
3

Yamamoto K, Tanaka H, Nakajima A, et al. Clinical outcomes of fluoride-resistant butyrylcholinesterase deficiency in Japanese patients: a prospective multicenter study. J Clin Anesth. 2021;68:110078.

clinical_trial2021
4

Manecke GR, Butterworth JF. Butyrylcholinesterase deficiency and anesthetic complications. In: Miller's Anesthesia. 9th ed. Elsevier; 2023:892-915.

other2023

Medication Comparisons

Compare medications used to treat Butyrylcholinesterase Deficiency Fluoride Resistant Japanese Type C1867469. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy