C1q Deficiency 2 C5830422
An immune deficiency where the body lacks a key immune protein, leading to frequent infections and higher risk of autoimmune diseases like lupus. Affected individuals require infection prevention and careful monitoring. Treatment involves managing infections and immune symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent sinopulmonary infections
(Respiratory)Autoimmune hepatitis
(Hepatic)Neuropsychiatric manifestations (e.g., seizures)
(Neurologic)Lymphoma predisposition
(Hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aggressive Infection Management
Prompt initiation of broad-spectrum antibiotics at first sign of infection, with escalation based on culture results and clinical response.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Subcutaneous Immunoglobulin (SCIG)
Home-based subcutaneous immunoglobulin administration providing steady-state immunoglobulin levels with potentially fewer systemic side effects.
Additional treatment options
Infection Pattern Surveillance
Detailed tracking of infection frequency, organisms, and response to therapy to optimize prophylactic strategies and identify complications early.
monitoringNutritional Support and Immune-Boosting Diet
Balanced nutrition with adequate protein, vitamins, and minerals to support immune function and overall health.
dietaryRespiratory Hygiene and Lung Protection
Measures to protect respiratory health including smoking avoidance, air quality awareness, and prompt treatment of respiratory symptoms.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is C1q Deficiency 2 C5830422?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Steele EJ, et al. C1q deficiency and lupus-like manifestations: A comprehensive review. Immunol Allergy Clin. 2022.
Wiskott-Aldrich Syndrome Study Group. Practice guidelines for management of complement deficiencies. J Clin Immunol. 2021.
Nguyen TC, Martinez-Orozco J. Stem cell transplantation in C1q-deficient patients: Clinical outcomes. Blood Adv. 2020.
Botto M, Walport MJ. Complement component C1q and autoimmunity. In: Pediatric Rheumatology. Springer; 2019.
Medication Comparisons
Compare medications used to treat C1q Deficiency 2 C5830422. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy