C6 Deficiency Subtotal C2676233
C6 deficiency is a complement disorder that increases risk of bacterial infections, particularly from certain organisms. Management involves infection prevention and prompt antibiotic treatment.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent Neisseria infections
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Lupus-like rash
(immunologic)Arthralgia
(immunologic)Fatigue
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic Prophylaxis for Neisseria
Lifelong antibiotic prophylaxis targeting Neisseria species is the cornerstone of management for terminal complement deficiency. Patient education on early infection recognition is critical.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Comprehensive Immunization
Up-to-date vaccination against Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b with appropriate boosters as immune response may be impaired.
Additional treatment options
Emergency Infection Treatment
Aggressive immediate empiric antibiotic therapy for suspected meningococcal or other encapsulated bacterial infections. Consider admission for observation even with mild symptoms.
medicationComplement and Infection Monitoring
Regular assessment of complement function and vigilance for infections. Document all infections thoroughly as this informs prognosis and management decisions.
monitoringPatient and Family Education Program
Comprehensive education on infection warning signs, emergency protocols, medical alert identification, and when to seek urgent care. Family members should understand the urgency of symptoms.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is C6 Deficiency Subtotal C2676233?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy