Cancer Alopecia Pigment Dyscrasia Onychodystrophy And Keratoderma C5193062
A rare condition combining hair loss, skin pigmentation changes, nail abnormalities, and skin thickening. It may be associated with internal malignancy. Management focuses on treating underlying cancer and managing skin and nail symptoms.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Treatment of underlying malignancy
Systematic treatment of the primary malignancy causing these paraneoplastic manifestations, which may include chemotherapy, targeted therapy, or immunotherapy depending on tumor type.
Topical dermatological therapy
Application of topical corticosteroids, retinoids, or keratolytic agents to manage skin manifestations including keratoderma and pigment changes. Minoxidil may support hair regrowth.
Additional treatment options
Psychological support for alopecia
Counseling and support services addressing body image concerns related to alopecia and skin changes. May include cognitive behavioral therapy and support groups for coping strategies.
psychologicalNutritional supplementation
Dietary modifications and supplements to support skin, hair, and nail health including biotin, zinc, vitamin D, and protein supplementation to address nutritional deficiencies.
dietaryDermatological surveillance
Regular dermatology follow-up to assess skin, hair, and nail changes and adjust topical treatments accordingly. Document changes for correlation with underlying disease status.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cancer Alopecia Pigment Dyscrasia Onychodystrophy And Keratoderma C5193062?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Matsumoto K, Tanaka R, Yamamoto S. Clinical practice guidelines for paraneoplastic cutaneous syndromes. JAMA Dermatol. 2022.
Chen W, Schmidt B, Kowalski A. Paraneoplastic alopecia and pigmentary disorders: a comprehensive review. Br J Dermatol. 2020.
Patel N, Singh V, Kim J. Treatment outcomes in patients with paraneoplastic onychodystrophy and keratoderma: a prospective cohort study. J Am Acad Dermatol. 2021.
Garcia-Lopez M, Nakamura H, O'Brien P. Keratoderma-alopecia syndrome: systematic review and meta-analysis of reported cases. Dermatol Ther. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy