Cdk4 Related Cutaneous Melanoma Cn379167
A hereditary form of skin cancer associated with an inherited CDK4 gene change. It can occur in families with multiple affected members. Treatment follows standard melanoma approaches including surgery and sometimes immunotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding or ulceration of the lesion
Regional lymph node swelling
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
New or changing mole
(integumentary)Itching or tenderness of the skin lesion
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide local excision with sentinel lymph node biopsy
Standard surgical approach with appropriate margins based on tumor thickness. Sentinel lymph node biopsy is recommended for intermediate-thickness melanomas to stage disease and guide adjuvant therapy decisions.
PD-1 inhibitor immunotherapy
Checkpoint inhibitor therapy that enhances anti-tumor immune response. Represents standard adjuvant treatment for high-risk resected melanoma and may be considered based on disease stage and genetic profile.
Additional treatment options
BRAF/MEK inhibitor targeted therapy
For patients with BRAF V600 mutations, combination targeted therapy may be appropriate. These oral agents inhibit specific signaling pathways driving melanoma growth.
medicationEnhanced dermatologic surveillance
Given genetic predisposition, comprehensive skin examinations at regular intervals with patient education on self-skin examination. Total body photography may aid in detecting new or changing lesions.
monitoringStrict sun protection and UV avoidance
Comprehensive photoprotection including broad-spectrum sunscreen, protective clothing, and avoidance of peak sun hours. Behavioral modifications are critical given underlying genetic susceptibility.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cdk4 Related Cutaneous Melanoma Cn379167?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sullivan RJ, Atkinson F, Thompson JA. NCCN Clinical Practice Guidelines for Melanoma Version 3.2023. J Natl Compr Canc Netw. 2023;21(5):432-478.
Hodis E, Watson IR, Kowalski LP. A landscape of driver mutations in melanoma. Cell. 2012;150(2):251-263.
Flaherty LE, Othus M, Atkins MB. Southwest Oncology Group S0008: High-dose interferon alfa-2b versus observation in resected high-risk melanoma. J Clin Oncol. 2014;32(31):3582-3590.
Korn EL, Liu PY, Lee SJ. Meta-analysis of phase II cooperative group trials in metastatic melanoma. J Clin Oncol. 2008;26(36):5918-5927.
Medication Comparisons
Compare medications used to treat Cdk4 Related Cutaneous Melanoma Cn379167. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy