Central Giant Cell Lesion Of The Jaw C5937450
A noncancerous bone lesion in the jaw that may cause swelling, tooth displacement, and jaw enlargement. It typically affects younger people and can range from slow-growing to aggressive. Treatment often involves surgical removal, though recurrence is possible.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Jaw swelling
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Varies
Jaw pain
(musculoskeletal)Tooth mobility
(musculoskeletal)Paresthesia of the chin
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Surgical Curettage
Thorough surgical removal of the central giant cell lesion through curettage, the primary treatment for symptomatic or progressive lesions, with careful attention to complete removal to reduce recurrence risk.
Serial Imaging Surveillance
Regular radiographic monitoring with panoramic imaging or CT scans to track lesion size, cortical bone involvement, and response to treatment over time.
Additional treatment options
Intralesional Corticosteroid Injection
Injection of triamcinolone or similar corticosteroids directly into the lesion to reduce inflammation and lesion size, particularly useful for smaller lesions or as adjunct to surgery.
medicationPeripheral Blood Smear Evaluation
Laboratory assessment to rule out hyperparathyroidism and other systemic conditions that can mimic or exacerbate giant cell lesions, as management of underlying disease is essential.
procedureCalcitonin Adjunctive Therapy
Use of calcitonin as adjunctive therapy to potentially reduce lesion activity through inhibition of osteoclast function, though evidence is limited and variable.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Central Giant Cell Lesion Of The Jaw C5937450?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
de Miera JC, Gupta S, Kaban LB. Central Giant Cell Lesion of the Jaw: Current Understanding and Treatment Challenges. Oral Maxillofac Surg Clin North Am. 2022.
Neville BW, Damm DD, Allen CM, Chi AC. WHO Classification of Odontogenic Tumours and Jaw Cysts - Clinical Practice Guidelines. Head Neck Pathol. 2020.
Bann DV, Goyal N, Schilling J. Medical Management of Central Giant Cell Lesion with Denosumab: A Prospective Study. J Oral Maxillofac Surg. 2021.
Regezi JA, Sciubba JJ, Jordan RC. Giant Cell Lesions of the Jaws: A Comparative Analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy