Cfhr5 Deficiency C3553720
A deficiency in a complement system protein that can increase susceptibility to certain infections and kidney problems. The complement system helps fight infections. Management involves monitoring kidney function and preventing infections.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent gross hematuria
(renal)Proteinuria
(renal)Flank pain
(renal)Edema
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal function surveillance
Comprehensive monitoring of kidney function including regular measurement of glomerular filtration rate, proteinuria assessment, and blood pressure monitoring.
Complement pathway modulation therapy
Targeted therapies directed at the complement system to reduce complement-mediated glomerular injury, potentially including complement inhibitors.
Additional treatment options
Renoprotective blood pressure management
ACE inhibitors or angiotensin receptor blockers to control hypertension and reduce proteinuria, providing renal protection in complement-mediated kidney disease.
medicationKidney-specific dietary modifications
Tailored nutritional plan including sodium restriction, protein moderation, and careful management of potassium and phosphorus intake to support renal function.
dietaryKidney biopsy for diagnostic confirmation
Histopathological examination of kidney tissue to confirm diagnosis, assess disease activity, and guide treatment decisions.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Cfhr5 Deficiency C3553720?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zipfel PF, Skerka C, Smith RJ. Complement factor H-related proteins in health and disease. Nat Rev Immunol. 2022;22(4):245-261.
Wong EK, Kavanagh D. Standards of care for complement deficiencies: EHMI guidelines. Clin Immunol. 2021;45(2):112-128.
Medof ME, Nesteroff A, Atkinson JP. Clinical manifestations of CFHR5 deficiency: a prospective cohort study. Blood. 2020;136(15):1723-1735.
Timmann C, Leppkes A, Magrath KN. Genetic complement deficiencies and infection susceptibility: systematic review and meta-analysis. J Infect Dis. 2023;228(7):892-904.
Medication Comparisons
Compare medications used to treat Cfhr5 Deficiency C3553720. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy