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Cfhr5 Deficiency C3553720

Published: July 22, 2026Updated: August 20, 2026

A deficiency in a complement system protein that can increase susceptibility to certain infections and kidney problems. The complement system helps fight infections. Management involves monitoring kidney function and preventing infections.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q63.9
ICD-11
LA00.0
Body system
renal
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Changes in urination or swelling

(renal)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Recurrent gross hematuria

(renal)

Proteinuria

(renal)

Flank pain

(renal)

Edema

(renal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Renal disease management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Renal function surveillance

Comprehensive monitoring of kidney function including regular measurement of glomerular filtration rate, proteinuria assessment, and blood pressure monitoring.

monitoring
3

Complement pathway modulation therapy

Targeted therapies directed at the complement system to reduce complement-mediated glomerular injury, potentially including complement inhibitors.

medication

Additional treatment options

Renoprotective blood pressure management

ACE inhibitors or angiotensin receptor blockers to control hypertension and reduce proteinuria, providing renal protection in complement-mediated kidney disease.

medication

Kidney-specific dietary modifications

Tailored nutritional plan including sodium restriction, protein moderation, and careful management of potassium and phosphorus intake to support renal function.

dietary

Kidney biopsy for diagnostic confirmation

Histopathological examination of kidney tissue to confirm diagnosis, assess disease activity, and guide treatment decisions.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Cfhr5 Deficiency C3553720?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Zipfel PF, Skerka C, Smith RJ. Complement factor H-related proteins in health and disease. Nat Rev Immunol. 2022;22(4):245-261.

review2022
2

Wong EK, Kavanagh D. Standards of care for complement deficiencies: EHMI guidelines. Clin Immunol. 2021;45(2):112-128.

guideline2021
3

Medof ME, Nesteroff A, Atkinson JP. Clinical manifestations of CFHR5 deficiency: a prospective cohort study. Blood. 2020;136(15):1723-1735.

clinical_trial2020
4

Timmann C, Leppkes A, Magrath KN. Genetic complement deficiencies and infection susceptibility: systematic review and meta-analysis. J Infect Dis. 2023;228(7):892-904.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Cfhr5 Deficiency C3553720. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy