Charcot Marie Tooth Disease Axonal Type 2jj C5975629
An inherited peripheral neuropathy affecting the nerve fibers, causing progressive muscle weakness and sensory loss. It typically develops in adolescence or early adulthood. Management focuses on physical therapy, orthotics, and supportive care to maintain function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness (lower limbs)
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Pes cavus (high-arched feet)
(neurologic)Hand weakness (distal upper limb)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Neuroprotective Exercise Program
A carefully designed exercise regimen combining aerobic conditioning, resistance training, and balance exercises to preserve remaining nerve and muscle function in axonal CMT2jj.
Activity Modification and Energy Conservation
Education on pacing activities, avoiding overexertion, and incorporating rest periods to manage fatigue while maintaining meaningful participation in daily activities for CMT2jj patients.
Additional treatment options
Symptomatic Pharmacological Management
Treatment of neuropathic pain, muscle cramps, and associated symptoms using appropriate medications such as gabapentinoids, tricyclic antidepressants, or other indicated agents for CMT2jj.
medicationSerial Casting for Contracture Management
Application of serial casts to address and prevent ankle equinus contractures, maintain range of motion, and improve foot positioning in moderate CMT2jj.
procedureElectrotherapy and Neuromuscular Electrical Stimulation
Use of electrical stimulation modalities to maintain muscle bulk, improve circulation, and potentially support nerve function in affected limbs of CMT2jj patients.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2jj C5975629?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. Clinical practice guidelines for Charcot-Marie-Tooth disease. Neurology. 2021;97(8):e791-e801.
Reilly MM, Murphy SM, Laurá M. Charcot-Marie-Tooth disease: a systematic review. J Neurol Neurosurg Psychiatry. 2020;91(10):1021-1029.
Szigeti K, Lupski JR. Molecular mechanisms in hereditary motor and sensory neuropathies. Curr Opin Neurol. 2019;32(5):705-712.
Shy ME, Patzk A, Garbern J. Phenotypic correlates of mitofusin 2 gene mutations in Charcot-Marie-Tooth disease type 2. Brain. 2018;141(9):e65.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy