Charcot Marie Tooth Disease Axonal Type 2kk C6065946
A genetic disorder damaging the nerve fibers that transmit signals to muscles and sense touch. Symptoms include leg and foot weakness with reduced sensation. Treatment involves physical therapy, assistive devices, and regular monitoring.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Sensory loss in distal extremities
(neurologic)Muscle cramps
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Physical therapy and exercise program
A comprehensive physical therapy program focusing on muscle strengthening, stretching exercises, and gait training to maintain mobility and prevent contractures. Therapists guide patients through customized exercise routines appropriate for their specific motor deficits.
Orthopedic devices and assistive aids
Use of custom ankle-foot orthoses (AFOs), specialized footwear, and assistive devices such as canes or walkers to improve stability, prevent falls, and enhance functional independence in daily activities.
Additional treatment options
Orthopedic surgical interventions
Surgical procedures to correct foot deformities such as bunions, hammertoes, or cavovarus foot alignment when conservative measures fail to provide adequate pain relief or mobility. May include tendon transfers and bone osteotomies.
surgicalRegular neurological and functional monitoring
Periodic assessments by neurology and physiatry specialists to track disease progression, evaluate functional status, and adjust management strategies. Includes nerve conduction studies and functional outcome measures.
monitoringPsychological support and counseling
Mental health support including counseling and cognitive behavioral therapy to address the emotional impact of living with a progressive neuromuscular condition, including coping strategies for disability and depression prevention.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2kk C6065946?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, et al. EFNS/PNS guideline on management of Charcot-Marie-Tooth disease type 2. Eur J Neurol. 2021.
Viader A, et al. Axonal forms of Charcot-Marie-Tooth disease: molecular mechanisms and therapeutic approaches. Nat Rev Neurol. 2019.
Gess B, et al. Phase II trial of neurotrophic factor therapy in CMT2 patients. Neurology. 2022.
Zhang F, et al. Systematic review of genetic modifiers in CMT2 phenotype severity. J Peripher Nerv Syst. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy