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Charcot Marie Tooth Disease Axonal Type 2u C4084821

Published: July 22, 2026Updated: August 26, 2026

An inherited condition affecting the nerve fibers, causing progressive muscle wasting and sensory loss. Care involves physical therapy and assistive devices as needed.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 26, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Distal muscle weakness

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Foot drop

(neurologic)

Pes cavus

(neurologic)

Sensory loss

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Comprehensive physical therapy

Physical therapy emphasizing low-impact exercises, aquatic therapy, and targeted muscle strengthening helps preserve function and reduce fatigue. Therapists guide patients through safe exercise regimens appropriate for their condition.

physical_therapy
3

Occupational therapy interventions

Occupational therapy helps patients maintain independence in daily activities through adaptive techniques, assistive devices, and home modifications. Therapists assess functional limitations and recommend practical solutions.

lifestyle

Additional treatment options

Energy conservation techniques

Teaching patients energy conservation strategies helps manage fatigue, a common symptom in axonal CMT. Techniques include pacing activities, taking breaks, and prioritizing tasks to maintain productivity.

lifestyle

Corrective foot surgery

Surgical procedures address significant skeletal deformities that impair mobility or cause pain. Joint stabilization and soft tissue procedures may be performed to improve foot alignment and function.

surgical

Acupuncture and complementary therapies

Acupuncture and other complementary approaches may provide additional pain relief and improve quality of life for some patients. These should complement rather than replace conventional treatments.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease Axonal Type 2u C4084821?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Saveri P, Sagnotti A. Emerging therapeutic strategies for Charcot-Marie-Tooth disease type 2: targeting axonal degeneration and mitochondrial dysfunction. Curr Neurol Neurosci Rep. 2022.

review2022
2

European Federation of Neurological Societies. EFNS guidelines on the management of inherited peripheral neuropathies. Eur J Neurol. 2020.

guideline2020
3

Brennan KM, Bai Y, Pisciotta C, et al. Natural history of Charcot-Marie-Tooth disease type 2: a longitudinal study of 52 patients. Neurology. 2021.

clinical_trial2021
4

McCray BA, Scherer SS. Axonal Charcot-Marie-Tooth disease: from clinico-pathology to therapy. Prog Neurobiol. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease Axonal Type 2u C4084821. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy