Charcot Marie Tooth Disease Axonal Type 2x C5569024
A hereditary nerve disorder affecting the peripheral nerves that carry signals to muscles and senses. It causes progressive weakness and sensory loss starting in the feet and hands. Treatment is supportive and includes physical therapy and orthotics.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Foot drop
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Distal muscle weakness
(neurologic)Sensory loss in lower extremities
(neurologic)Pes cavus foot deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Neuromuscular rehabilitation
Comprehensive physical therapy focusing on strength maintenance, gait training, balance exercises, and prevention of contractures. Customized exercise programs slow disease progression and maintain function.
Orthotic support devices
Custom ankle-foot orthoses, foot inserts, and supportive footwear to stabilize gait, prevent ankle instability, and reduce fatigue during ambulation. Proper fitting essential for comfort and effectiveness.
Additional treatment options
Neuropathic pain management
Pharmacological treatment of burning pain, paresthesias, and neuropathic symptoms using appropriate agents. Treatment typically starts with gabapentinoids or tricyclic antidepressants.
medicationOrthopedic reconstructive surgery
Surgical interventions for foot deformities including tendon transfers, osteotomies, and joint fusions to improve gait mechanics and reduce pain when conservative measures fail.
surgicalChronic disease counseling
Psychological support addressing depression, anxiety, and adjustment to progressive disability. Coping strategies and vocational guidance for young adults managing hereditary condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2x C5569024?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shy ME, Lupski JR, Chance PF, et al. Clinical practice guidelines for inherited neuropathies. Peripheral Nerve Society. 2022.
Pareyson D, Saveri P, Pisciotta C. New developments in Charcot-Marie-Tooth disease and related disorders. Curr Opin Neurol. 2020.
Fridman V, Reilly MM, Lewis RA, et al. Natural history of axonal Charcot-Marie-Tooth disease type 2: a prospective multicenter study. Brain. 2021.
Higuchi Y, Takashima H. Genetic basis of axonal Charcot-Marie-Tooth disease. J Neurol Neurosurg Psychiatry. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy