Charcot Marie Tooth Disease Axonal Type 2z C5569025
An inherited condition damaging the peripheral nerves, leading to muscle weakness, atrophy, and sensory changes typically beginning in the lower legs. Physical therapy and assistive devices help manage symptoms and maintain mobility.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Foot drop
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Distal muscle weakness
(neurologic)Sensory loss in lower extremities
(neurologic)Pes cavus foot deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Motor rehabilitation program
Structured PT program emphasizing distal muscle strengthening, proprioceptive training, and functional mobility exercises. Aquatic therapy may reduce joint stress while maintaining cardiovascular fitness.
Assistive device utilization
Integration of walking aids such as canes, walkers, or wheeled walkers as disease progresses. Home modifications including grab bars, ramps, and adaptive equipment maintain independence.
Additional treatment options
Pain symptom control
Management of musculoskeletal and neuropathic pain components using multimodal approach. May include NSAIDs, neuropathic agents, and topical analgesics depending on pain etiology.
medicationFoot and ankle reconstruction
Corrective surgery for cavovarus foot deformity, ankle instability, or hammertoes. Procedures may include tendon transfers, osteotomies, and arthrodesis to improve weight-bearing mechanics.
surgicalOccupational therapy
OT focusing on hand function preservation, energy conservation techniques, and adaptive strategies for activities of daily living. Hand therapy addresses intrinsic muscle weakness and fine motor decline.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2z C5569025?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C. Diagnosis and management of Charcot-Marie-Tooth disease subtypes: clinical practice guidelines. Neurology. 2022.
Rossor A, Polke J, Houlden H. Clinical and genetic heterogeneity in hereditary motor and sensory neuropathies. J Peripher Nerv Syst. 2021.
Ginsberg M, Yum S. Phase II trial of targeted therapy for axonal Charcot-Marie-Tooth disease. Lancet Neurol. 2023.
Singh N, Lombardi V, Chen X. Efficacy of rehabilitation interventions in hereditary neuropathies: systematic review and meta-analysis. Brain. 2020.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease Axonal Type 2z C5569025. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy