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Charcot Marie Tooth Disease Axonal Type 2z C5569025

Published: July 22, 2026Updated: August 20, 2026

An inherited condition damaging the peripheral nerves, leading to muscle weakness, atrophy, and sensory changes typically beginning in the lower legs. Physical therapy and assistive devices help manage symptoms and maintain mobility.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Foot drop

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Distal muscle weakness

(neurologic)

Sensory loss in lower extremities

(neurologic)

Pes cavus foot deformity

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Motor rehabilitation program

Structured PT program emphasizing distal muscle strengthening, proprioceptive training, and functional mobility exercises. Aquatic therapy may reduce joint stress while maintaining cardiovascular fitness.

physical_therapy
3

Assistive device utilization

Integration of walking aids such as canes, walkers, or wheeled walkers as disease progresses. Home modifications including grab bars, ramps, and adaptive equipment maintain independence.

lifestyle

Additional treatment options

Pain symptom control

Management of musculoskeletal and neuropathic pain components using multimodal approach. May include NSAIDs, neuropathic agents, and topical analgesics depending on pain etiology.

medication

Foot and ankle reconstruction

Corrective surgery for cavovarus foot deformity, ankle instability, or hammertoes. Procedures may include tendon transfers, osteotomies, and arthrodesis to improve weight-bearing mechanics.

surgical

Occupational therapy

OT focusing on hand function preservation, energy conservation techniques, and adaptive strategies for activities of daily living. Hand therapy addresses intrinsic muscle weakness and fine motor decline.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease Axonal Type 2z C5569025?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Marchesi C. Diagnosis and management of Charcot-Marie-Tooth disease subtypes: clinical practice guidelines. Neurology. 2022.

guideline2022
2

Rossor A, Polke J, Houlden H. Clinical and genetic heterogeneity in hereditary motor and sensory neuropathies. J Peripher Nerv Syst. 2021.

review2021
3

Ginsberg M, Yum S. Phase II trial of targeted therapy for axonal Charcot-Marie-Tooth disease. Lancet Neurol. 2023.

clinical_trial2023
4

Singh N, Lombardi V, Chen X. Efficacy of rehabilitation interventions in hereditary neuropathies: systematic review and meta-analysis. Brain. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease Axonal Type 2z C5569025. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy