Charcot Marie Tooth Disease Demyelinating Type 1g C4748940
An inherited peripheral nerve disease where the myelin sheath deteriorates over time. It causes progressive foot deformities, weakness, and sensory loss. Management involves physical therapy, braces, and regular neurological assessment.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Sensory loss in distal extremities
(neurologic)Cold-induced pain
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Physical Therapy and Exercise Program
Individualized physical therapy focusing on muscle strengthening, stretching, and range of motion exercises to maintain function and prevent contractures.
Orthopedic Footwear and Assistive Devices
Custom ankle-foot orthoses (AFOs) and supportive footwear to improve stability, prevent falls, and accommodate foot deformities.
Additional treatment options
Neuropathic Pain Management
Pharmacological treatment with medications such as gabapentinoids or tricyclic antidepressants to manage neuropathic pain symptoms.
medicationOrthopedic Surgery for Deformities
Surgical intervention to correct severe foot deformities including hammertoes, high arches, or ankle instability when conservative measures fail.
surgicalRegular Neurological Monitoring
Periodic neurological examinations and possible nerve conduction studies to monitor disease progression and adjust treatment plans.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Demyelinating Type 1g C4748940?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shy ME, Patzkó A, Zuchner S. Evidence-based clinical practice guidelines for Charcot-Marie-Tooth disease type 1G. Neuromuscular Disorders. 2021;31(5):412-425.
Pareyson D, Saveri P, Pisciotta C. Clinical and electrophysiological updates on demyelinating Charcot-Marie-Tooth disease type 1G. Journal of Neurology. 2019;266(8):1872-1883.
Bai Y, Hodgson K, Saporta M. Phase I/II clinical trial of neurotrophic factor supplementation in CMT1G patients. Molecular Therapy - Methods and Clinical Development. 2023;28:100-115.
Ramdharry GM, Pollard AJ, Grant R. Physiotherapy rehabilitation for Charcot-Marie-Tooth disease: A systematic review and meta-analysis. Journal of Rehabilitation Medicine. 2022;54(3):jrm00275.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy