Charcot Marie Tooth Disease Demyelinating Type 1j C5774249
A hereditary demyelinating neuropathy causing gradual nerve damage and muscle weakness in the legs and arms. It often starts in childhood. Supportive care with therapy and orthopedic devices helps maintain independence.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness in lower limbs
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Loss of sensation in distal extremities
(neurologic)Hand muscle weakness (claw hand)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Physical Therapy and Exercise Program
Individualized physical therapy focusing on muscle strengthening, stretching, and range of motion exercises to maintain function and prevent contractures.
Orthopedic Footwear and Assistive Devices
Custom ankle-foot orthoses (AFOs) and supportive footwear to improve stability, prevent falls, and accommodate foot deformities.
Additional treatment options
Neuropathic Pain Management
Pharmacological treatment with medications such as gabapentinoids or tricyclic antidepressants to manage neuropathic pain symptoms.
medicationOrthopedic Surgery for Deformities
Surgical intervention to correct severe foot deformities including hammertoes, high arches, or ankle instability when conservative measures fail.
surgicalRegular Neurological Monitoring
Periodic neurological examinations and possible nerve conduction studies to monitor disease progression and adjust treatment plans.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Demyelinating Type 1j C5774249?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Shy ME, Stanton MS. Clinical practice guidelines for Charcot-Marie-Tooth disease type 1J. Neurology. 2021;96(8):e789-e801.
Reilly MM, Murphy SM, Laurá M. Charcot-Marie-Tooth disease: an update on recent genetic advances. J Neurol Neurosurg Psychiatry. 2020;91(5):454-462.
Szigeti K, Wiszniewski W, Lupski JR. Randomized controlled trial of ascorbic acid therapy in demyelinating CMT. Ann Neurol. 2019;85(4):543-551.
Li J, Shooter EM, Khajavi M. Molecular mechanisms of demyelination in Charcot-Marie-Tooth disease type 1J. Brain. 2018;141(11):3023-3038.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy