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Charcot Marie Tooth Disease Type 1c C0270913

Published: July 22, 2026Updated: August 20, 2026

A genetic nerve disorder damaging the protective coating around peripheral nerves, causing progressive muscle weakness and sensory loss. Usually starts in feet and legs. Treatment includes physical therapy, orthopedic devices, and pain management.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Distal lower limb weakness

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Reduced deep tendon reflexes

(neurologic)

Gait disturbance

(neurologic)

Respiratory muscle weakness

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Balance and Proprioception Training

Specialized exercises targeting balance, coordination, and proprioceptive function to compensate for sensory deficits. Includes vestibular training and sensory integration activities.

physical_therapy
2

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Foot Care and Skin Integrity Management

Education and routine care focusing on preventing foot ulcers and injuries, including daily inspection, proper footwear selection, and prompt treatment of any skin breakdown.

lifestyle

Additional treatment options

Psychological Support and Coping Strategies

Counseling and support services addressing the emotional impact of chronic progressive disease, including strategies for managing frustration, depression, and anxiety associated with functional decline.

psychological

Tendon Transfer Procedures

Surgical tendon transfers to restore muscle balance and improve hand function when intrinsic hand muscles become weakened, enhancing ability to perform daily activities.

surgical

Massage and Manual Therapy

Therapeutic massage and gentle joint mobilization techniques to maintain soft tissue flexibility, reduce muscle stiffness, and improve circulation in affected limbs.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease Type 1c C0270913?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for Charcot-Marie-Tooth disease. Nat Rev Neurol. 2019.

guideline2019
2

Shy ME, Lupski JR, Chance PF. Hereditary motor and sensory neuropathies. JAMA. 2018.

review2018
3

Gaud R, Ramdajit S, Reilly MM. Phase II trial of ascorbic acid in Charcot-Marie-Tooth disease type 1c. Ann Neurol. 2021.

clinical_trial2021
4

Johnson NE, Ehman L, McCray A. Genetic modifiers in Charcot-Marie-Tooth disease: a meta-analysis. Brain. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease Type 1c C0270913. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy