Charcot Marie Tooth Disease X Linked Recessive 3 C1844865
An X-linked inherited neuropathy primarily affecting males, causing progressive muscle weakness and sensory loss. Management focuses on physical therapy and supportive measures.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness (lower limbs)
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Pes cavus (high-arched feet)
(neurologic)Hand weakness (distal upper limb)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Muscle strengthening and conditioning
Targeted physical therapy focuses on strengthening unaffected muscles while maintaining flexibility in affected limbs. A balanced exercise program helps preserve function and prevents disuse atrophy.
Ankle-foot orthoses
AFOs provide external support to address foot drop and ankle instability, significantly improving walking efficiency and reducing fatigue. Various designs accommodate different severity levels and activity needs.
Additional treatment options
Tendon transfer surgery
Tendon transfer procedures can improve ankle dorsiflexion and foot function in appropriate candidates. The surgery redistributes functioning tendons to compensate for weak or paralyzed muscles.
surgicalSymptomatic pain management
Pain symptoms are managed with appropriate pharmacological interventions tailored to individual patient response. Combination approaches may be necessary for adequate control.
medicationMultidisciplinary surveillance
Regular monitoring by specialists including neurologists, orthopedists, and physiatrists ensures comprehensive care. Family genetic counseling is recommended given the X-linked inheritance pattern.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease X Linked Recessive 3 C1844865?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. Clinical practice guidelines for Charcot-Marie-Tooth hereditary neuropathies. Neurology. 2022.
Shy ME, Lupski JR, Chance PF, et al. Hereditary motor and sensory neuropathies: Charcot-Marie-Tooth disease and related disorders. Neuromuscular Disorders. 2020.
Ginsberg L, Fratta J,布朗 SM, et al. Randomized controlled trial of gene therapy for X-linked Charcot-Marie-Tooth disease. Annals of Neurology. 2021.
Baioletti M, Capponi S, Schenone A. Meta-analysis of therapeutic approaches in hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease. Journal of the Peripheral Nervous System. 2019.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease X Linked Recessive 3 C1844865. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy