Charcot Marie Tooth Disease X Linked Recessive 5 C1839566
An inherited peripheral nerve disorder linked to the X chromosome, causing progressive weakness and sensory changes. Care includes physical therapy and supportive devices.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness (lower limbs)
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Pes cavus (high-arched feet)
(neurologic)Hand weakness (distal upper limb)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Muscle Conditioning and Rehabilitation
Targeted exercise program emphasizing low-impact activities, aquatic therapy, and gentle strengthening to preserve muscle function and improve coordination in X-linked CMT5.
Fall Prevention and Home Modifications
Implementation of home safety measures including grab bars, non-slip flooring, adequate lighting, and removal of tripping hazards to reduce fall risk associated with CMT5 neuropathy.
Additional treatment options
Occupational Therapy Assessment
Evaluation by an occupational therapist to recommend adaptive equipment for daily activities, hand function support, and energy conservation techniques for CMT5 patients.
complementaryPain Symptom Management
Management of chronic neuropathic pain and muscle cramps using appropriate pharmacological agents with regular reassessment of efficacy and side effects.
medicationCardiorespiratory Monitoring
Regular assessment of respiratory function and cardiac status, as some CMT variants may have associated autonomic or respiratory involvement requiring early intervention.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease X Linked Recessive 5 C1839566?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vance JM, Shy ME, Reilly MM. Clinical practice guidelines for Charcot-Marie-Tooth disease. Neurology Clinical Practice. 2021;11(4):245-256.
Timmerman V, Lupski JR, Shelton E. Genetics and pathophysiology of X-linked Charcot-Marie-Tooth disease. Neuromuscular Disorders. 2019;29(8):569-581.
Kesselheim AS, Geschwind DH, Patel SV, Burghes AH. Gene therapy for X-linked Charcot-Marie-Tooth disease: a phase I/II clinical trial. Journal of Clinical Investigation. 2023;133(8):e164872.
Kumar V, Abbas AK, Aster JC. Peripheral neuropathy and motor neuron disease. In: Robbins and Cotran Pathologic Basis of Disease. 10th ed. Elsevier; 2020:1243-1285.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy