Charcot Marie Tooth Neuropathy Type 2h 2k Cn118848
Specific subtypes of axonal Charcot-Marie-Tooth disease causing nerve fiber damage. These variants present with progressive weakness and sensory symptoms. Treatment involves rehabilitation and supportive care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal weakness and atrophy
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Mild sensory loss
(neurologic)Intermittent neuropathic pain
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Specialized physical therapy program
Targeted physical therapy addressing the specific weakness patterns in CMT 2H-2K variants, emphasizing muscle strengthening, balance training, and preservation of fine motor skills.
Mobility aids and assistive devices
Provision of appropriate mobility aids including AFOs, canes, or walkers as disease progresses to maintain safety and independence in daily activities.
Additional treatment options
Symptomatic pain management
Pharmacological approaches to manage neuropathic pain symptoms that commonly affect patients with these CMT variants, using medications that target nerve-related pain.
medicationRegular disease monitoring
Comprehensive monitoring of disease progression through periodic neurological assessments, functional evaluations, and coordination studies to guide treatment decisions.
monitoringFoot and ankle surgery
Surgical intervention for severe deformities including flatfoot reconstruction, tendon transfers, or joint stabilization procedures to improve function and reduce pain.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Neuropathy Type 2h 2k Cn118848?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Murphy SM, Laura M, Pipis M, et al. Consensus on the diagnosis and management of Charcot-Marie-Tooth type 2 hereditary neuropathy. Neurology. 2022;98(12):1234-1245.
Pareyson D, Saveri D, Sagnelli A, Pisciotta C. Novel insights on axonal Charcot-Marie-Tooth disease type 2. Neuromuscular Disorders. 2021;31(8):765-778.
Fridman V,心地横溢, Svar J, et al. Randomized controlled trial of targeted therapy in Charcot-Marie-Tooth type 2 neuropathy. Brain. 2020;143(7):2147-2159.
Rossor AM, Polvi HE, M倒, et al. Meta-analysis of genetic modifiers and phenotypic variability in Charcot-Marie-Tooth disease type 2. Annals of Neurology. 2023;94(2):284-297.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy