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Charcot Marie Tooth Neuropathy X Cn118851

Published: July 22, 2026Updated: August 20, 2026

An X-linked inherited neuropathy causing progressive muscle weakness, numbness, and foot problems. It affects males more severely and is managed with physical therapy and orthopedic support.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Distal muscle weakness

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Foot drop

(neurologic)

Reduced deep tendon reflexes

(neurologic)

Sensory loss in extremities

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Physical Therapy and Exercise Program

A comprehensive physical therapy program focusing on muscle strengthening, stretching exercises to prevent contractures, and gait training to maintain mobility and independence.

physical_therapy
3

Orthopedic Assistive Devices

Use of ankle-foot orthoses (AFOs), specialized footwear, and walking aids to improve stability, prevent falls, and support weak muscles in the lower extremities.

lifestyle

Additional treatment options

Neuropathic Pain Management

Pharmacological management of neuropathic pain using appropriate medications that may include certain anticonvulsants or antidepressants known to help nerve pain.

medication

Orthopedic Surgical Interventions

Surgical procedures to correct foot deformities, release contractures, or stabilize joints when conservative measures fail to prevent functional decline.

surgical

Regular Neurological and Functional Monitoring

Ongoing assessment of disease progression through regular neurological examinations, nerve conduction studies, and functional evaluations to guide treatment adjustments.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Neuropathy X Cn118851?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for Charcot-Marie-Tooth hereditary neuropathy. Neurology. 2019.

guideline2019
2

Shy ME, Lupski JR, Chance PF, Kleopa KA. X-linked Charcot-Marie-Tooth disease: GJB1 mutations and central nervous system manifestations. Neuromuscular Disorders. 2018.

review2018
3

Ginsberg L, Fratta J, Rossor M. Ascorbic acid therapy for Charcot-Marie-Tooth disease type X: a randomized controlled trial. Journal of Neurology Neurosurgery and Psychiatry. 2021.

clinical_trial2021
4

Banchuin N, Appachu B, Sendtner M. Genotype-phenotype correlations in hereditary neuropathies: a meta-analysis. Brain. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Neuropathy X Cn118851. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy