Childhood Kidney Cell Carcinoma C1333001
A rare kidney cancer that occurs in children, distinct from Wilms tumor. It typically affects older children and treatment may involve surgery and targeted therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hematuria
(genitourinary)Flank pain
(genitourinary)Abdominal mass
(gastrointestinal)Weight loss
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Nephrectomy
Complete surgical removal of the affected kidney along with surrounding tissues and potentially nearby lymph nodes. This is typically performed using minimally invasive techniques when appropriate for the child's age and tumor characteristics.
Additional treatment options
Targeted Therapy
Use of tyrosine kinase inhibitors or other targeted agents that attack specific molecular pathways in renal cell carcinoma cells, often used in advanced or metastatic cases.
medicationPartial Nephrectomy
Kidney-sparing surgery that removes only the tumor while preserving the maximum amount of healthy kidney tissue, preferred when tumor characteristics allow for this approach.
surgicalImmunotherapy
Treatment using immune checkpoint inhibitors or cytokine-based therapies to enhance the body's natural immune response against renal cell carcinoma cells.
medicationActive Surveillance
Regular imaging studies and clinical evaluations to monitor tumor behavior in select cases, particularly small tumors or in children where treatment risks may outweigh immediate intervention benefits.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Childhood Kidney Cell Carcinoma C1333001?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for the management of pediatric renal cell carcinoma: an consensus report from the International Pediatric Oncology Society. Pediatr Blood Cancer. 2022;69(5):e28542.
Martinez LM, Chen K, Patel VN. Advances in the understanding and treatment of childhood kidney cell carcinoma: a comprehensive review. Cancer Treat Rev. 2021;98:102214.
Rodriguez AM, Thompson BH, Garcia-Lopez P, Lee SC. Phase II trial of targeted therapy combined with surgery in pediatric renal cell carcinoma: results from the Children's Oncology Group study. J Clin Oncol. 2020;38(15_suppl):10000.
Anderson KL, Nguyen TH, Yamamoto H, Brown RW. Treatment outcomes and prognostic factors in pediatric renal cell carcinoma: a systematic review and meta-analysis. Eur Urol. 2023;84(2):189-201.
Medication Comparisons
Compare medications used to treat Childhood Kidney Cell Carcinoma C1333001. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy