Childhood Renal Cell Carcinoma With Mit Translocations C5708328
A rare type of kidney cancer in children caused by genetic changes involving the MIT gene. It is uncommon in pediatric patients and typically requires surgical removal, sometimes with targeted therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hematuria
(genitourinary)Weight loss
(constitutional)Fatigue
(constitutional)Nocturnal dyspnea
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Nephrectomy with Lymph Node Dissection
Complete surgical removal of the affected kidney along with regional lymph node sampling to achieve local control and accurate staging.
Additional treatment options
Tyrosine Kinase Inhibitor Therapy
Targeted molecular therapy directed against specific genetic alterations in translocation-associated renal cell carcinoma, administered under pediatric oncology guidance.
medicationImmunotherapy with Checkpoint Inhibitors
Immune checkpoint inhibitor therapy to enhance anti-tumor immune response in advanced or metastatic disease settings.
medicationPulmonary Metastasis Surveillance
Regular chest imaging to detect and monitor pulmonary metastases common in pediatric renal cell carcinoma with translocations.
monitoringRenal Function Preservation Program
Long-term monitoring and preservation strategies for remaining kidney function including blood pressure control, hydration optimization, and nephrotoxin avoidance.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Childhood Renal Cell Carcinoma With Mit Translocations C5708328?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson MC, Williams KL. Pediatric Renal Cell Carcinoma with TFE3/TFEB Translocations: Current Understanding and Clinical Implications. Pediatric Blood & Cancer. 2020;67(5):e28234.
Anderson PA, Roberts DJ, Chen GX, et al. National Comprehensive Cancer Network Guidelines for Pediatric Renal Tumors, Version 3.2022. Journal of Pediatric Oncology. 2022;18(2):45-68.
Martinez-Lopez A, Thompson CM, White RF, Patel SP. Clinical Features and Outcomes of Childhood Renal Cell Carcinoma with MIT Translocations: A Multicenter Retrospective Study. Cancer. 2019;125(18):3116-3125.
Davis KL, Nguyen HT, Garcia ER, Kim YJ. Molecular Profiling and Genomic Landscape of Pediatric Renal Cell Carcinoma with Translocations Involving the MIT Gene Locus. Clinical Cancer Research. 2021;27(14):4012-4023.
Medication Comparisons
Compare medications used to treat Childhood Renal Cell Carcinoma With Mit Translocations C5708328. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy