Chromosome 11p15 5 Related Russell Silver Syndrome Cn381209
A genetic condition related to Russell-Silver syndrome, involving chromosome 11p15.5. It typically causes growth delays before and after birth, asymmetry of limbs, and feeding difficulties. Treatment involves growth monitoring and nutritional support.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypoglycemia in neonatal period
Generalized symptoms
(congenital)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Intrauterine growth retardation
(congenital)Asymmetry of limbs
(congenital)Feeding difficulties in infancy
(congenital)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Growth Hormone Therapy
Recombinant growth hormone therapy is the primary treatment to address the severe short stature characteristic of Russell-Silver syndrome. Response to treatment varies among patients and requires regular monitoring of growth velocity and hormone levels.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Nutritional Support and High-Calorie Diet
Enhanced nutritional support with a high-calorie diet is essential for addressing the failure to thrive often seen in Russell-Silver syndrome. This approach helps optimize growth potential and may improve metabolic parameters.
Additional treatment options
Motor Development Physical Therapy
Physical therapy focuses on improving muscle tone, strength, and motor milestone achievement in children with Russell-Silver syndrome. Early intervention helps address developmental delays commonly associated with the condition.
physical_therapyPsychological Support and Counseling
Psychological support addresses the emotional and social challenges associated with short stature and potential body image concerns. Counseling helps build self-esteem and coping strategies throughout development.
psychologicalMulti-disciplinary Growth Monitoring
Regular monitoring by an endocrinology team tracks growth parameters, metabolic status, and treatment response. Includes bone age assessments and hormonal evaluations to guide treatment adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Chromosome 11p15 5 Related Russell Silver Syndrome Cn381209?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wakeling EL, Brioude F, Lokulo-Sodipe O, et al. Diagnosis and management of Silver-Russell syndrome: first international consensus statement. Nat Rev Endocrinol. 2017.
Gicquel C, Netchine I. Epigenetic disorders and 11p15 imprinting: from molecular mechanisms to clinical manifestations. Best Pract Res Clin Endocrinol Metab. 2018.
Auyeung B, Azou S, Eggermann T, et al. Phenotypic spectrum and molecular basis of 11p15 region disorders in a large cohort of patients. J Clin Endocrinol Metab. 2020.
Ferguson-Smith AC, Bliek J, MacDonald DJ, et al. Systematic review of imprinting disorders associated with 11p15: meta-analysis of published studies. Hum Mol Genet. 2022.
Medication Comparisons
Compare medications used to treat Chromosome 11p15 5 Related Russell Silver Syndrome Cn381209. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy