Classic Salt Wasting 21 Ohd Cah Cn381243
A hormonal disorder affecting the adrenal glands, causing the body to lose salt and produce excess male hormones. Can cause life-threatening crises in newborns. Lifelong hormone replacement therapy is the main treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Glucocorticoid and Mineralocorticoid Replacement Therapy
Lifelong hormone replacement with hydrocortisone (glucocorticoid) and fludrocortisone (mineralocorticoid) to compensate for deficient adrenal hormone production. Dosing requires individualization and regular monitoring.
Stress-Dose Steroid Protocol
Increased glucocorticoid dosing during illness, surgery, or trauma to prevent adrenal crisis. Patients and caregivers must be educated on sick day rules and emergency injection techniques.
Additional treatment options
Regular Hormone Level and Growth Monitoring
Periodic assessment of hormone levels, growth parameters, bone age, and metabolic markers to optimize treatment dosing and detect complications early.
monitoringMedical Alert Identification and Emergency Preparedness
Wearing medical alert jewelry and carrying emergency information to ensure appropriate care during emergencies or unconsciousness.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Classic Salt Wasting 21 Ohd Cah Cn381243?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy