Clear Cell Carcinoma Of Kidney C0279702
The most common type of kidney cancer in adults. May cause blood in urine or flank pain. Treatment typically involves surgery to remove part or all of the kidney, sometimes with additional therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gross hematuria
(urinary)Flank pain
(musculoskeletal)Palpable abdominal mass
(abdominal)Unexplained weight loss
(systemic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Partial or Radical Nephrectomy
Surgical removal of the tumor and affected kidney tissue, with partial nephrectomy preferred when feasible to preserve renal function.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Tyrosine Kinase Inhibitor Targeted Therapy
Systemic therapy with agents like sunitinib or pazopanib that inhibit tumor angiogenesis and growth pathways in advanced or metastatic disease.
medicationImmunotherapy with Checkpoint Inhibitors
Treatment with agents such as nivolumab or pembrolizumab to enhance immune response against cancer cells, often used in advanced disease.
medicationThermal Ablation Therapy
Image-guided percutaneous ablation using radiofrequency or cryoablation for small tumors, offering a minimally invasive alternative to surgery in select patients.
procedureActive Surveillance for Small Renal Masses
Careful monitoring with periodic imaging for small tumors that meet criteria for observation, avoiding treatment-related morbidity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Clear Cell Carcinoma Of Kidney C0279702?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Motzer RJ, Jonasch E, Agarwal N, et al. Kidney Cancer, Version 3.2022. NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022.
Hsieh JJ, Purdue MP, Signoretti S, et al. Renal cell carcinoma. Nat Rev Dis Primers. 2017.
Choueiri TK, Escudier B, Powles T, et al. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial. Lancet Oncol. 2016.
Wang Y, Li G, Wan F, et al. Prognostic value of PD-L1 expression in patients with clear cell renal cell carcinoma: a systematic review and meta-analysis. Oncotarget. 2017.
Medication Comparisons
Compare medications used to treat Clear Cell Carcinoma Of Kidney C0279702. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy