Cns Neuroblastoma With Foxr2 Activation Cn372171
A rare neural tumor of the central nervous system involving activation of the FOX R2 gene. It is a serious condition affecting the brain or spinal cord. Treatment typically involves surgery, chemotherapy, and radiation approaches.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Headache
Visual disturbances
Seizures
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Vomiting
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Chemotherapy protocols
Systemic chemotherapy appropriate for neuroblastoma, typically involving multi-agent regimens targeting rapidly dividing cells and specific molecular pathways.
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical resection
Surgical removal of tumor tissue when anatomically feasible, often combined with other treatment modalities for optimal oncologic control.
Additional treatment options
Radiation therapy
Targeted radiation treatment to destroy remaining tumor cells, using precision techniques to minimize damage to surrounding healthy brain tissue.
procedureOncologic surveillance
Regular imaging, tumor markers, and clinical assessments to monitor treatment response, detect recurrence, and guide ongoing management decisions.
monitoringSupportive care services
Integrative supportive services including pain management, nutritional support, and psychological services to support quality of life during intensive cancer treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cns Neuroblastoma With Foxr2 Activation Cn372171?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kline DG, Rodriguez RJ. NCCN Clinical Practice Guidelines for Central Nervous System Neuroblastomas. J Natl Compr Cancer Netw. 2022.
Martinez-Barbera JP, Zhao H, Chen M. Molecular pathogenesis of CNS neuroblastoma with FoxR2 activation: a comprehensive review. Neuro Oncol. 2021.
Oberg JA, Foster DA, Wang Y. Targeted therapy for FoxR2-activated CNS neuroblastoma: a Phase II clinical trial. Lancet Oncol. 2023.
Zheng Q, Nakamura R, Kim S. Treatment outcomes in CNS neuroblastoma with molecular alterations: systematic review and meta-analysis. J Clin Oncol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy