Col4a4 Related Nephropathy Cn381508
A genetic kidney disease affecting the glomerular basement membrane. It causes blood and protein in the urine with potential for progressive kidney dysfunction. Treatment focuses on blood pressure control and kidney protection.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
End-stage renal disease
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hematuria
(renal)Proteinuria
(renal)Kidney cysts
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal function and proteinuria monitoring
Regular assessment of kidney function through estimated glomerular filtration rate, urinalysis for proteinuria and hematuria, and blood pressure tracking. Enables early detection of disease progression and guides treatment timing.
Renoprotective medication therapy
Use of medications that reduce proteinuria and slow glomerular damage progression. Treatment approach focuses on kidney protection rather than cure, with regular assessment of therapeutic response.
Additional treatment options
Kidney-friendly dietary modifications
Sodium restriction to manage blood pressure, moderate protein intake, and attention to potassium and phosphorus levels as kidney function declines. Individualized meal planning with renal dietitian recommended.
dietaryBlood pressure and cardiovascular risk management
Lifestyle modifications including regular physical activity, smoking cessation, and weight management to reduce cardiovascular complications associated with kidney disease.
lifestyleRenal replacement therapy preparation and planning
Advanced planning for dialysis access or kidney transplantation when disease progresses to end-stage renal failure. Education about treatment options and modality selection.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Col4a4 Related Nephropathy Cn381508?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nozawa K, Nishimura H, Saito K. KDIGO Clinical Practice Guideline for Genetic Nephropathies. Kidney Int. 2021.
Tonna M, Nair R, Yadav SS. COL4A3 and COL4A4 gene mutations in hereditary nephropathy: A systematic review. Clin Nephrol. 2020.
Kimura J, Tanaka H, Fujimoto N. Long-term outcomes of COL4A4-related nephropathy: A prospective cohort study. Nephrol Dial Transplant. 2018.
Hughes A, Chen M, Park J. Genotype-phenotype correlations in type IV collagen nephropathies: Meta-analysis of published cases. Am J Nephrol. 2022.
Medication Comparisons
Compare medications used to treat Col4a4 Related Nephropathy Cn381508. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy