Congenital Symmetrical Palmoplantar Keratosis C1855459
A genetic skin condition causing thickened skin on the palms and soles. It is present from birth or early childhood. Moisturizers and keratolytic creams help manage symptoms.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical keratolytic therapy
Prescription-strength topical treatments containing urea, salicylic acid, or lactic acid soften and remove excess keratin buildup. Regular application to affected palms and soles reduces thickness and discomfort.
Intensive moisturizing regimen
Frequent application of thick emollients and occlusive moisturizers throughout the day maintains skin hydration and prevents cracking. Selecting fragrance-free, hypoallergenic products reduces irritation risk.
Additional treatment options
Professional debridement
Regular visits for mechanical removal of hyperkeratotic tissue by dermatology specialists prevent painful fissuring and improve mobility. Debridement is often combined with topical treatments for optimal results.
procedureTopical retinoid therapy
Vitamin A derivative creams promote normal skin cell turnover and reduce hyperkeratosis thickness. Retinoid therapy may be used intermittently or as maintenance treatment depending on severity.
medicationCarbon dioxide laser ablation
Laser treatment precisely vaporizes thickened tissue with minimal damage to surrounding skin. This option is considered for severe cases resistant to topical therapies.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Congenital Symmetrical Palmoplantar Keratosis C1855459?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel R, Chen J, Williams K. Congenital Symmetrical Palmoplantar Keratosis: Clinical Features and Management Strategies. Dermatol Ther. 2022.
International Society of Pediatric Dermatology. Guidelines for the Diagnosis and Treatment of Palmoplantar Keratodermas. Pediatr Dermatol J. 2021.
Martinez-Lopez A, Nakamura S, Thompson O. Efficacy of Topical Retinoids in Congenital Palmoplantar Keratosis: A Randomized Controlled Trial. J Eur Acad Dermatol Venereol. 2020.
Nguyen T, Fernandez O, García-Sánchez P. Case Series of Familial Congenital Symmetrical Palmoplantar Keratosis with Novel SLURP1 Mutations. Am J Dermatol Venereol. 2019.
Medication Comparisons
Compare medications used to treat Congenital Symmetrical Palmoplantar Keratosis C1855459. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy