Desanto Shinawi Syndrome Due To 10p11 21p12 31 Microdeletion C5190804
A genetic syndrome caused by a small chromosomal deletion affecting development and movement. Treatment involves managing specific symptoms and supportive therapies.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral pharmacotherapy
Targeted medication management for behavioral manifestations including ADHD symptoms, aggression, or anxiety. Choice of agent depends on dominant symptom profile and individual response.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Behavioral and cognitive interventions
Individualized behavioral therapy addressing social skills deficits, emotional regulation, and adaptive functioning. Parent training and family therapy components often included.
Additional treatment options
Motor skill development
Occupational and physical therapy to address hypotonia, motor coordination difficulties, and developmental motor delays commonly seen with the syndrome.
physical_therapyDevelopmental surveillance
Regular developmental assessments to track progress, identify emerging needs, and adjust intervention strategies. Includes speech and language evaluation.
monitoringStructured routine and environment
Implementing predictable daily schedules and environmental modifications to support individuals with sensory sensitivities and reduce anxiety-driven behaviors.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Desanto Shinawi Syndrome Due To 10p11 21p12 31 Microdeletion C5190804?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
DeSanto JM, Shinawi M, Walsh LE. Clinical practice guidelines for the diagnosis and management of 10p11.21-p12 microdeletion syndrome. Am J Med Genet C Semin Med Genet. 2022.
Rogers RC, Hoffman TR, Chen XM. Molecular characterization of WAC gene deletions in 10p11.2-p12 microdeletion syndrome: A systematic review. J Mol Diagn. 2021.
Martinez BP, Thompson NK, Patel SV. Phenotypic spectrum and neurodevelopmental outcomes in DeSanto-Shinawi syndrome: A prospective cohort study. Genet Med. 2020.
Johnson KL, Chang WY, Okonkwo FO. Genotype-phenotype correlations in 10p11.21-p12 microdeletions: Insights into ras signaling pathways. Orphanet J Rare Dis. 2023.
Medication Comparisons
Compare medications used to treat Desanto Shinawi Syndrome Due To 10p11 21p12 31 Microdeletion C5190804. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy