Developmental And Epileptic Encephalopathy 78 C5231409
A severe genetic disorder causing drug-resistant epilepsy and significant developmental impairment in children. Treatment focuses on seizure management and supportive interventions.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Seizures
(neurologic)Intellectual disability
(neurologic)Ataxia
(neurologic)Cardiac arrhythmia
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-seizure medication therapy
First-line pharmacological management using appropriate anti-seizure medications tailored to seizure type. Treatment selection requires careful evaluation by a neurologist experienced in pediatric epilepsy syndromes.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Ketogenic diet therapy
A high-fat, low-carbohydrate diet that may help reduce seizure frequency in medication-resistant cases. Requires supervision by a metabolic specialist and dietitian to ensure nutritional adequacy.
Additional treatment options
Continuous EEG monitoring
Extended electroencephalogram monitoring to characterize seizure patterns and guide treatment decisions. Helps identify subclinical seizures that may affect developmental outcomes.
monitoringNeurodevelopmental physical therapy
Specialized physical therapy addressing motor delays, tone abnormalities, and functional mobility limitations commonly associated with encephalopathies. Focuses on developmental progression and prevention of secondary complications.
physical_therapyVagus nerve stimulation
An implanted device that delivers electrical stimulation to the vagus nerve, which may reduce seizure frequency in refractory cases. Requires surgical evaluation and ongoing device management.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Developmental And Epileptic Encephalopathy 78 C5231409?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy