Diamond Blackfan Anemia 2 C1853666
A rare genetic blood disorder where bone marrow fails to produce enough red blood cells. Usually appears in infancy and is treated with medications, transfusions, or stem cell transplant.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pallor
(hematologic)Thumb abnormalities
(musculoskeletal)Craniofacial anomalies
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
Similar to DBA1, corticosteroids serve as first-line pharmacotherapy for Diamond-Blackfan anemia type 2, with many patients achieving transfusion independence. Treatment response patterns may differ between subtypes.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Chronic transfusion therapy
For DBA2 patients who are steroid-resistant or experience significant steroid side effects, scheduled red blood cell transfusions maintain oxygen-carrying capacity and quality of life.
procedureStem cell transplantation
Curative option for eligible DBA2 patients with transfusion-dependent disease. Successful transplantation can eliminate the need for ongoing transfusions and steroid therapy.
surgicalImmunosuppressive therapy
For steroid-resistant or steroid-intolerant DBA2 patients, immunosuppressive agents such as cyclosporine may be attempted as steroid-sparing alternatives to induce red blood cell production.
medicationSupportive care and multidisciplinary management
Coordinated care involving hematology, genetics, nutrition, and psychology addresses the complex needs of DBA2 patients. Developmental support and psychosocial care complement disease-directed therapies.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diamond Blackfan Anemia 2 C1853666?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy