Diarrhea Negative Hemolytic Uremic Syndrome C1268937
A rare disorder affecting blood vessels and kidneys, causing abnormal blood cell breakdown and kidney problems. Treated with complement inhibitors and supportive care.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hemolytic anemia
(renal)Thrombocytopenia
(renal)Acute kidney injury
(renal)Hypertension
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement inhibitor therapy
Eculizumab inhibits terminal complement activation, preventing endothelial damage in thrombotic microangiopathy. This targeted therapy addresses the underlying pathophysiology of atypical hemolytic uremic syndrome.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma exchange therapy
Therapeutic plasma exchange removes autoantibodies and circulating immune complexes while replacing deficient complement factors. This procedure is particularly beneficial during acute exacerbations.
Additional treatment options
Renal replacement therapy
Dialysis support provides renal function replacement when acute kidney injury leads to fluid overload, electrolyte imbalances, or uremia. Temporary dialysis may be required until renal function recovers.
procedureHematologic monitoring
Regular monitoring of platelet counts, LDH, haptoglobin, and peripheral blood smear detects disease activity and treatment response. Frequency increases during acute phases.
monitoringAntihypertensive management
Blood pressure control protects renal function and reduces cardiovascular complications. ACE inhibitors or ARBs may provide additional renal protection when proteinuria is present.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diarrhea Negative Hemolytic Uremic Syndrome C1268937?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy