Diffuse Hemispheric Glioma H3 G34 Mutant C5669880
A malignant brain tumor that develops in the cerebral hemispheres, more common in adolescents and young adults. Treatment involves surgery, radiation, and chemotherapy, though outcomes are generally poor.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Headache
Seizures
Hemiparesis
Personality changes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Outpatient procedure with monitoring
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Surgical Debulking
Aggressive but careful surgical removal of hemispheric tumor mass to reduce symptom burden and improve effectiveness of adjuvant therapies. Neuro-navigation and intraoperative mapping guide resection.
Intensity-Modulated Radiation Therapy
Precision radiation targeting the tumor region with enhanced sparing of surrounding healthy brain tissue. Sophisticated planning accounts for tumor location within the cerebral hemispheres.
Additional treatment options
Molecularly-Targeted Therapy
Use of agents targeting specific genetic alterations in H3 G34 mutant gliomas. Treatment selection guided by molecular profiling of the tumor tissue.
medicationClinical Trial Enrollment
Participation in investigational studies evaluating novel therapeutic approaches including immunotherapy, targeted agents, and innovative combination strategies specific to H3-mutant gliomas.
complementaryNeuropsychological Support
Cognitive assessment and intervention to address memory, attention, and executive function changes. Provides coping strategies and educational support for patients and families.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Diffuse Hemispheric Glioma H3 G34 Mutant C5669880?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012.
Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology. 2021.
Korshunov A, Chavez L, Sharma T, et al. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly more favorable entities compared to patient-matched, conventional control samples. Acta Neuropathologica. 2021.
Huang TY, Piunti A, Shilati BH, et al. Hemispheric hemispheric glioma H3 G34 mutant: clinical, pathological and molecular characteristics. Neuropathology. 2023.
Medication Comparisons
Compare medications used to treat Diffuse Hemispheric Glioma H3 G34 Mutant C5669880. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy