Diffuse Large B Cell Lymphoma Of The Central Nervous System C2026186
A rare, aggressive lymphoma that develops in the brain or spinal cord. Treatment involves intensive chemotherapy and sometimes radiation, with variable outcomes depending on individual factors.
Key facts at a glance
- ICD-10
- C83.398, C83.30, C83.3A
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Headache
Seizure
Focal neurological deficit (e.g., weakness or numbness)
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Cognitive impairment
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
High-dose methotrexate-based chemotherapy
High-dose intravenous methotrexate (often 3.5-8 g/m²) with leucovorin rescue forms the cornerstone of primary CNS lymphoma treatment, given its superior CNS penetration and proven efficacy.
Additional treatment options
Rituximab with methotrexate
Addition of rituximab to methotrexate-based regimens may improve outcomes, particularly in CD20-positive tumors, though evidence is less robust than for systemic lymphoma.
medicationWhole-brain radiotherapy
Historically standard treatment, now often reserved for patients who cannot tolerate chemotherapy or have refractory disease, due to delayed neurotoxicity especially in older patients.
procedureOmmaya reservoir placement
Intraventricular catheter system allowing direct intrathecal chemotherapy delivery, which may be beneficial for certain tumor locations or when systemic methotrexate is contraindicated.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diffuse Large B Cell Lymphoma Of The Central Nervous System C2026186?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy