Diffuse Large B Cell Lymphoma With Chronic Inflammation C4511460
A rare lymphoma that arises in areas of long-term inflammation. Treatment includes chemotherapy, and outcomes depend on the location, stage, and underlying cause.
Key facts at a glance
- ICD-10
- C83.3A, C83.32, C83.30
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Lymphadenopathy
(hematologic)Unexplained weight loss
(hematologic)Night sweats
(hematologic)Pruritus
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy
Combination chemotherapy using rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This is the standard first-line immunochemotherapy regimen for diffuse large B-cell lymphoma, targeting cancer cells while preserving immune function.
Additional treatment options
Autologous Stem Cell Transplant
High-dose chemotherapy followed by reinfusion of patient's own stem cells to restore bone marrow function. This consolidation approach is considered after achieving remission with primary therapy for eligible patients with higher-risk disease.
procedurePolatuzumab Vedotin with Immunochemotherapy
Targeted antibody-drug conjugate therapy combined with bendamustine and rituximab for relapsed or refractory disease. This novel approach delivers cytotoxic agents directly to CD79b-expressing lymphoma cells.
medicationSerial PET-CT Surveillance
Regular imaging with positron emission tomography combined with CT scanning to assess treatment response and detect early relapse. Response assessment typically occurs after 2-4 cycles of chemotherapy.
monitoringNutritional Support and Infection Prevention
Comprehensive nutritional counseling to maintain adequate caloric and protein intake during treatment, combined with infection precautions including food safety practices and vaccination review. This supportive care approach helps maintain treatment tolerance and quality of life.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Diffuse Large B Cell Lymphoma With Chronic Inflammation C4511460?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy